如何使用 SQL 通过分组和 CASE 连接两行

Question

我在 SQL Server 2016 Express 中有一些基因组数据，它目前采用长格式，包含参考基因组和测试基因组，由 SubjectID、基因和密码子分割（例如 3 元组）。

我真正需要的是将我的数据重塑为元组连接在一起的数据，但仅当元组中存在突变（与参考基因组相比）时。这将是一种对每个人都更有用的格式。

我的数据是这样的

DECLARE @myTable TABLE 
(
     SubjectID VARCHAR(MAX), 
     country VARCHAR(MAX), 
     gene VARCHAR(MAX), 
     position INT, 
     ReferenceNucleotide VARCHAR(1), 
     TestNucleotide VARCHAR(1), 
     codon INT, 
     nucleotide_order INT 
)

INSERT INTO @myTable 
VALUES
('1-0002','India','gyrA',   65,'A','x', 92,1),
('1-0002','India','gyrA',   66,'T','x', 92,2),
('1-0002','India','gyrA',   67,'C','C', 92,3),
('1-0002','India','gyrA',   68,'T','T', 93,1),
('1-0002','India','gyrA',   69,'A','A', 93,2),
('1-0002','India','gyrA',   70,'C','C', 93,3),
('1-0002','India','gyrA',   71,'G','G', 94,1),
('1-0002','India','gyrA',   72,'A','A', 94,2),
('1-0002','India','gyrA',   73,'C','C', 94,3),
('1-0002','India','gyrA',   74,'A','A', 95,1),
('1-0002','India','gyrA',   75,'G','C', 95,2),
('1-0002','India','gyrA',   76,'C','C', 95,3),
('1-0002','India','gyrA',   77,'C','C', 96,1),
('1-0002','India','gyrA',   78,'T','T', 96,2),
('1-0002','India','gyrA',   79,'G','N', 96,3)

但是，有几个条件

如果参考基因组和测试基因组的所有三个核苷酸都相同，我想要 'WT'
如果核苷酸有任何差异，我想要测试基因组的三元组（按核苷酸顺序）
我需要按 SubjectID 和基因分组，因为我有很多受试者和基因

我的结果看起来像

1-0002 India gyrA 92 xxC
1-0002 India gyrA 93 WT
1-0002 India gyrA 94 WT
1-0002 India gyrA 95 ACC
1-0002 India gyrA 96 CTN

我可以确定需要三元组的密码子在哪里，但我正在为如何连接它们而苦苦挣扎

DECLARE @myCodons TABLE (SubjectID varchar(max), country varchar(max), gene  varchar(max), codon int, WT int)

INSERT INTO @myCodons
    SELECT 
        SubjectID, country, gene, codon,
        SUM(CASE WHEN RefNucleotide=TestNucleotide THEN 0 ELSE 1 END) AS WT
    FROM 
        @myTable
    GROUP BY 
        SubjectID, country, gene, codon 

SELECT * 
FROM @myCodons 
ORDER BY codon

Answer 1

从以下内容开始：

select T1.SubjectID, T1.country, T1.gene, T1.codon, 
    T1.RefGenome + T2.RefGenome + T3.RefGenome RefGenome,
    T1.TestGenome + T2.TestGenome + T3.TestGenome TestGenome
from @myTable T1
    inner join @myTable T2 on T1.SubjectID = T2.SubjectID and T1.country = T2.country
        and T1.gene = T2.gene and T1.codon = T2.codon and T2.nucleotide_order = 2
    inner join @myTable T3 on T1.SubjectID = T3.SubjectID and T1.country = T3.country
        and T1.gene = T3.gene and T1.codon = T3.codon and T3.nucleotide_order = 3
where T1.nucleotide_order = 1

然后您可以在此基础上使用 case 语句来确定是显示测试基因组还是 'WT'

Answer 2

可能有用的替代方法：

select SubjectID, country, gene, codon, case when RefGenomeStr = TestGenomeStr then 'WT' else TestGenomeStr end wanted_string
from @myTable t1
cross apply(
    SELECT
        STUFF((
              SELECT
                    ', ' +RefGenome
              FROM @myTable t2
              WHERE t2.SubjectID= t1.SubjectID and t2.country = t1.country and  t2.gene = t1.gene and t2.codon = t1.codon
              FOR XML PATH ('')
              )
             , 1, 1, '')
      , STUFF((
              SELECT
                    ', ' +TestGenome
              FROM @myTable t2
              WHERE t2.SubjectID= t1.SubjectID and t2.country = t1.country and  t2.gene = t1.gene and t2.codon = t1.codon
              FOR XML PATH ('')
              )
             , 1, 1, '')
         ) ca (RefGenomeStr,TestGenomeStr)    
where nucleotide_order = 1

结果：

+----+-----------+---------+------+-------+---------------+
|    | SubjectID | country | gene | codon | wanted_string |
+----+-----------+---------+------+-------+---------------+
|  1 | 1-0002    | India   | gyrA |    92 |  x, x, C      |
|  2 | 1-0002    | India   | gyrA |    93 | WT            |
|  3 | 1-0002    | India   | gyrA |    94 | WT            |
|  4 | 1-0002    | India   | gyrA |    95 |  A, C, C      |
|  5 | 1-0002    | India   | gyrA |    96 |  C, T, N      |
+----+-----------+---------+------+-------+---------------+

Demo

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